| Name | Polyphyllin VI | ||
| PubChem CID | 10417550 | ||
| Molecular Weight | 738.9g/mol | ||
| Formula | C₃₉H₆₂O₁₃ | ||
| SMILES | CC1CCC2(C(C3(C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)C)O)O)O)C)C)O)C)OC1 | ||
| InChI | 1S/C39H62O13/c1-18-8-13-38(47-17-18)20(3)39(46)27(52-38)15-25-23-7-6-21-14-22(9-11-36(21,4)24(23)10-12-37(25,39)5)49-35-33(31(44)29(42)26(16-40)50-35)51-34-32(45)30(43)28(41)19(2)48-34/h6,18-20,22-35,40-46H,7-17H2,1-5H3/t18-,19+,20-,22+,23-,24+,25+,26-,27+,28+,29-,30-,31+,32-,33-,34+,35-,36+,37+,38-,39-/m1/s1 | ||
| InChIKey | WHWWQGPCTUQCMN-JDDKMXSSSA-N | ||
| CAS Number | 55916-51-3 | ||
| ChEMBL ID | CHEMBL478738 | ||
| ChEBI ID | CHEBI:228900 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ZhongLou | ||
| Use Part | Rhizome | ||
| Habitat | YunNan, GuiZhou, GuangDong, GuangXi, HuBei | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Liliaceae
-->Family: Liliaceae
-->Genus: Paris
-->Species: Paris polyphylla
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| Pair Name | Polyphyllin VI, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Up-regulation | Expression | BECN1 | hsa8678 | |
| Up-regulation | Expression | MAP1LC3A | hsa84557 | |
| In Vitro Model | DLD-1 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0248 |
| Result | Our results suggest that EEPP deserves further evaluation for development as complementary chemotherapy for colorectal cancer. | |||
